مقایسه موسین موجود در سلولهای مخاط معده بیماران مبتلا به گاستریت هلیکوباکترپیلوری با افراد طبیعی

ABSTRACT Gastric cancer (GC) is one of the most common cancers in the world. Despite some improvement in the treatment of this type of cancer, the 5-year survival rate has been already remained low. Therefore further exploration of biological features and causes of gastric cancer is needed to reduce its occurrence. In sequential changes from superficial gastritis to dysplasia and cancer, intestinal metaplasia (IM) plays a pivotal role. Most investigators agree that the risk of GC is proportional to the extent IM and as a possible premalignant lesion. According to the differences in enzyme production and mucus content two types of IM have been identified. The different variants of (IM) may exhibit different risks of GC development, thus incomplete type that changes neutral mucin to acidic mucin shows stranger risk. In this study the influences of H.pylori on gastric cancer has been evaluated and also to detect premalignant lesion before morphological changes, combined PAS/Alcian blue (PH=2.5) stain is performed for distintion of two types of mucin. This study was performed in a series of 100 cases of chronic gastritis with H.pylori, 20 cases of gastritis and IM and 10 cases of chronic gastritis without H.pylori (negative control). Combined PAS/Alcian blue (PH=2.5) stain performed for distinction between neutral and acidic mucin. According to this staining, no changes in mucin (neutral mucin) is observed in H.pylori gastritis without intestinal metaplasia. In this study we found that neutral mucin is not changed in H.pylori gastritis without IM, however for better interpretation study in a large number and cases is recommended. Key Words: 1) Gastric carcinoma 2) Intestinal metaplasia 3) H.pylori 4) Mucin